Invention Grant
US08088816B2 3-3-di-substituted-oxindoles as inhibitors of translation initiation
有权
3-3-二取代羟吲哚作为翻译起始的抑制剂
- Patent Title: 3-3-di-substituted-oxindoles as inhibitors of translation initiation
- Patent Title (中): 3-3-二取代羟吲哚作为翻译起始的抑制剂
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Application No.: US12796787Application Date: 2010-06-09
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Publication No.: US08088816B2Publication Date: 2012-01-03
- Inventor: José A. Halperin , Amarnath Natarajan , Huseyin Aktas , Yun-Hua Fan , Han Chen
- Applicant: José A. Halperin , Amarnath Natarajan , Huseyin Aktas , Yun-Hua Fan , Han Chen
- Applicant Address: US MA Cambridge
- Assignee: President and Fellows of Harvard College
- Current Assignee: President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge
- Agency: Banner & Witcoff, Ltd.
- Main IPC: A61K31/404
- IPC: A61K31/404
Abstract:
Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl) -3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using 3-(5-tert-butyl-2-hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are described.
Public/Granted literature
- US20100249201A1 3-3-Di-Substituted-Oxindoles As Inhibitors of Translation Initiation Public/Granted day:2010-09-30
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