Invention Grant
US08088887B2 Peptide-conjugates that bind to VEGF-stimulated or tumor vasculature and methods of treatment
有权
结合VEGF刺激或肿瘤脉管系统的肽缀合物和治疗方法
- Patent Title: Peptide-conjugates that bind to VEGF-stimulated or tumor vasculature and methods of treatment
- Patent Title (中): 结合VEGF刺激或肿瘤脉管系统的肽缀合物和治疗方法
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Application No.: US11783926Application Date: 2007-04-13
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Publication No.: US08088887B2Publication Date: 2012-01-03
- Inventor: Han-Chung Wu , Chin-Tarng Lin , Tong-Young Lee , Szu-Yao Kuo
- Applicant: Han-Chung Wu , Chin-Tarng Lin , Tong-Young Lee , Szu-Yao Kuo
- Applicant Address: TW Taipei TW Taipei
- Assignee: Academia Sinica,National Taiwan University
- Current Assignee: Academia Sinica,National Taiwan University
- Current Assignee Address: TW Taipei TW Taipei
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/18 ; C07K2/00 ; C07K4/00 ; C07K5/00 ; C07K7/00 ; C07K14/00 ; C07K16/00 ; C07K17/00 ; C07K14/515 ; A61P35/00
Abstract:
The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target neovasculature and were identified by in vivo phage display. One such peptide, SP5-52, recognized the neovasculature of multiple tumors in SCID mice, but did not target normal blood vessels. This peptide also binds to blood vessels of human lung cancer biopsy specimens. Liposomes comprising SP5-52 and doxorubicin enhanced the efficacy of the drug against multiple human cancer xenografts in SCID mice.
Public/Granted literature
- US20080193510A1 Peptides that target to tumor blood vessels of lung cancer and applications thereof Public/Granted day:2008-08-14
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