Invention Grant
US08088907B2 Detection of mutations in a gene associated with resistance to viral infection, OAS1
有权
检测与病毒感染相关的基因中的突变，OAS1
- Patent Title: Detection of mutations in a gene associated with resistance to viral infection, OAS1
- Patent Title (中): 检测与病毒感染相关的基因中的突变，OAS1
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Application No.: US12061548Application Date: 2008-04-02
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Publication No.: US08088907B2Publication Date: 2012-01-03
- Inventor: Shawn P. Iadonato , Charles L. Magness , Gary Rosenberg , Christina A. Scherer , Thierry Guillaudeux
- Applicant: Shawn P. Iadonato , Charles L. Magness , Gary Rosenberg , Christina A. Scherer , Thierry Guillaudeux
- Applicant Address: US WA Seattle
- Assignee: Kineta Two, LLC
- Current Assignee: Kineta Two, LLC
- Current Assignee Address: US WA Seattle
- Agency: K&L Gates LLP
- Main IPC: C07H21/04
- IPC: C07H21/04
Abstract:
A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided.
Public/Granted literature
- US20090123472A1 DETECTION OF MUTATIONS IN A GENE ASSOCIATED WITH RESISTANCE TO VIRAL INFECTION, OAS1 Public/Granted day:2009-05-14
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