Invention Grant
- Patent Title: Hyaluronic acid-methotrexate conjugate
- Patent Title (中): 透明质酸 - 甲氨蝶呤结合物
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Application No.: US10591653Application Date: 2005-03-04
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Publication No.: US08088916B2Publication Date: 2012-01-03
- Inventor: Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi
- Applicant: Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi
- Applicant Address: JP Tokyo
- Assignee: Denki Kagaku Kogyo Kabushiki Kaisha
- Current Assignee: Denki Kagaku Kogyo Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Browdy and Neimark, PLLC
- Priority: JP2004-062616 20040305; JP2004-167755 20040604
- International Application: PCT/JP2005/003739 WO 20050304
- International Announcement: WO2005/085294 WO 20050915
- Main IPC: C08B37/00
- IPC: C08B37/00 ; A01N43/04 ; A01N43/60
Abstract:
An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases.There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids.
Public/Granted literature
- US20070197465A1 Hyaluronic Acid-Methotrexate Conjugate Public/Granted day:2007-08-23
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