Methods of encoding and decoding a multi-channel audio signal and apparatuses for encoding and decoding a multi-channel audio signal are provided. The method of decoding a multi-channel audio signal includes an unpacking unit which extracts a quantized CLD between a pair of channels of a plurality of channels from a bitstream, and an inverse quantization unit which inverse-quantizes the quantized CLD using a quantization table that considers the location properties of the pair of channels. The methods of encoding and decoding a multi-channel audio signal and the apparatuses for encoding and decoding a multi-channel audio signal can enable an efficient encoding/decoding by reducing the number of quantization bits required.