A system and method for high performance secure access to a trusted platform module on a hardware virtualization platform. The virtualization platform including Virtual Machine Monitor (VMM) managed components coupled to the VMM. One of the VMM managed components is a TPM (Trusted Platform Module). The virtualization platform also includes a plurality of Virtual Machines (VMs). Each of the virtual machines includes a guest Operating System (OS), a TPM device driver (TDD), and at least one security application. The VMM creates an intra-partition in memory for each TDD such that other code and information at a same or higher privilege level in the VM cannot access the memory contents of the TDD. The VMM also maps access only from the TDD to a TPM register space specifically designated for the VM requesting access. Contents of the TPM requested by the TDD are stored in an exclusively VMM-managed protected page table that provides hardware-based memory isolation for the TDD.