Invention Grant
US08093046B2 CVN-12p1: a recombinant allosteric lectin antagonist of HIV-1 envelope gp120 interactions
失效
CVN-12p1：HIV-1信封gp120相互作用的重组变构凝集素拮抗剂
- Patent Title: CVN-12p1: a recombinant allosteric lectin antagonist of HIV-1 envelope gp120 interactions
- Patent Title (中): CVN-12p1：HIV-1信封gp120相互作用的重组变构凝集素拮抗剂
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Application No.: US11756567Application Date: 2007-05-31
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Publication No.: US08093046B2Publication Date: 2012-01-10
- Inventor: Karyn McFadden , Irwin M. Chaiken
- Applicant: Karyn McFadden , Irwin M. Chaiken
- Applicant Address: US PA Philadelphia
- Assignee: Philadelphia Health and Education Corporation d/b/c Drexel University College of Medicine
- Current Assignee: Philadelphia Health and Education Corporation d/b/c Drexel University College of Medicine
- Current Assignee Address: US PA Philadelphia
- Agency: Riverside Law LLP
- Main IPC: C12N5/02
- IPC: C12N5/02 ; C07K7/00 ; G01N33/53 ; A61K39/00
Abstract:
The invention provides a recombinant multi-functional chimera of CVN and 12p1. Chimeras of CVN and 12p1 present a model for targeting gp120 at two discrete sites, by two different modes of inhibition and with increasing potency versus either component alone. A chimera of the invention combines the high affinity suppression of viral activity by CVN with the allosteric suppression of viral envelope binding to both CD4 and co-receptor by 12p1.
Public/Granted literature
- US20090233850A1 CVN-12p1: a recombinant allosteric lectin antagonist of HIV-1 envelope gp120 interactions Public/Granted day:2009-09-17
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