Invention Grant
US08093213B2 Heparin binding epidermal growth factor (HB-EGF) for use in methods of treating and preventing intestinal injury related to hemorrhagic shock and resuscitation
有权
肝素结合表皮生长因子（HB-EGF）用于治疗和预防与出血性休克和复苏有关的肠损伤的方法
- Patent Title: Heparin binding epidermal growth factor (HB-EGF) for use in methods of treating and preventing intestinal injury related to hemorrhagic shock and resuscitation
- Patent Title (中): 肝素结合表皮生长因子（HB-EGF）用于治疗和预防与出血性休克和复苏有关的肠损伤的方法
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Application No.: US12598082Application Date: 2008-04-28
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Publication No.: US08093213B2Publication Date: 2012-01-10
- Inventor: Gail E. Besner , Osama N. El-Assal
- Applicant: Gail E. Besner , Osama N. El-Assal
- Applicant Address: US OH Columbus
- Assignee: Nationwide Children's Hospital, Inc.
- Current Assignee: Nationwide Children's Hospital, Inc.
- Current Assignee Address: US OH Columbus
- Agency: Marshall, Gerstein & Borun LLP
- International Application: PCT/US2008/061772 WO 20080428
- International Announcement: WO2008/134635 WO 20081106
- Main IPC: A61K38/18
- IPC: A61K38/18
Abstract:
The invention is related to methods of protecting, preventing and reducing intestinal injury in a human subject suffering from or at risk for shock, hemorrhagic shock or hemorrhagic shock and resuscitation (HS/R) comprising administering heparin binding epidermal growth factor (HB-EGF). The invention is also related to methods of inhibiting deterioration of intestinal blood flow and methods of preserving and increasing intestinal blood flow by administering HB-EGF to a human subject. In addition, the methods of the invention should improve the clinical outcome of human subject suffering from or at risk for shock, hemorrhagic shock or hemorrhagic shock and resuscitation.
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