Invention Grant
- Patent Title: Methods and compositions for inhibition of multi-drug resistance by hyaluronan oligomers
- Patent Title (中): 用透明质酸低聚物抑制多药耐药的方法和组合物
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Application No.: US10835511Application Date: 2004-04-29
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Publication No.: US08093217B2Publication Date: 2012-01-10
- Inventor: Bryan P. Toole , Suniti Misra , Shibnath Ghatak
- Applicant: Bryan P. Toole , Suniti Misra , Shibnath Ghatak
- Applicant Address: US MA Boston
- Assignee: Tufts University
- Current Assignee: Tufts University
- Current Assignee Address: US MA Boston
- Agency: Lawson & Weitzen, LLP
- Agent Sonia K. Guterman; Michael I. Falkoff
- Main IPC: A01N61/00
- IPC: A01N61/00 ; A61K31/00 ; A61K38/00
Abstract:
Pharmaceutical compositions and methods for sensitizing multi-drug resistant cancer or radiation resistant cancer cells to chemotherapeutic agents are provided. Compositions include ligands of hyaluronan receptors, including glycosaminoglycans such as hyaluronan oligomers and derivatives of these oligomers, hyaluronan binding proteins, antibodies specific for hyaluronan receptors, hyaluronan mimetics, inhibitors of hyaluronan synthesis, and stimulators of hyaluronan degradation.
Public/Granted literature
- US20040229843A1 Methods and compositions for inhibition of multi-drug resistance by hyaluronan oligomers Public/Granted day:2004-11-18
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