Invention Grant
US08093235B2 Macrocyclic compounds which stabilize G-Quadruplex DNA and RNA
有权
稳定G-Quadruplex DNA和RNA的大环化合物
- Patent Title: Macrocyclic compounds which stabilize G-Quadruplex DNA and RNA
- Patent Title (中): 稳定G-Quadruplex DNA和RNA的大环化合物
-
Application No.: US12258208Application Date: 2008-10-24
-
Publication No.: US08093235B2Publication Date: 2012-01-10
- Inventor: Edmond J. Lavoie , Joseph E. Rice , Leroy F. Liu
- Applicant: Edmond J. Lavoie , Joseph E. Rice , Leroy F. Liu
- Applicant Address: US NJ New Brunswick US NJ Somerset
- Assignee: Rutgers, The State University of New Jersey,University of Medicine and Dentistry of New Jersey
- Current Assignee: Rutgers, The State University of New Jersey,University of Medicine and Dentistry of New Jersey
- Current Assignee Address: US NJ New Brunswick US NJ Somerset
- Agency: Viksnins Harris & Padys PLLP
- Main IPC: A61K31/33
- IPC: A61K31/33 ; C07D513/00 ; C07D245/00
Abstract:
The invention provides compounds of formula I: wherein A, B, D, E, R1, R2, R3, R4, R5, X, and ----- have any values defined herein, as well as salts thereof. The compounds have activity as G-quadruplex DNA stabilizers and as anti-proliferative agents.
Public/Granted literature
- US20090156627A1 THERAPEUTIC COMPOUNDS Public/Granted day:2009-06-18
Information query
