Invention Grant
- Patent Title: Alpha 7 nicotinic receptor selective ligands
- Patent Title (中): α7烟碱受体选择性配体
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Application No.: US11921832Application Date: 2006-06-07
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Publication No.: US08093269B2Publication Date: 2012-01-10
- Inventor: William R. Kem , Ferenc Soti
- Applicant: William R. Kem , Ferenc Soti
- Applicant Address: US FL Gainesville
- Assignee: University of Florida Research Foundation
- Current Assignee: University of Florida Research Foundation
- Current Assignee Address: US FL Gainesville
- Agency: Edwards Wildman Palmer LLP
- Agent Peter F. Corless; Weiying Yang
- International Application: PCT/US2006/022136 WO 20060607
- International Announcement: WO2006/133303 WO 20061214
- Main IPC: C07D401/04
- IPC: C07D401/04 ; A61K31/44
Abstract:
The invention relates to the design and synthesis of 3-arylidene-anabaseine compounds that exhibit enhanced selectivity toward alpha7 nicotinic receptors. The compounds are expected to be useful in treating a wide variety of conditions, including neurodegenerative conditions such as Alzheimer's Disease, neurodevelopmental diseases such as schizophrenia, and certain peripherally located inflammations mediated by macrophage infiltration.
Public/Granted literature
- US20090215705A1 Alpha 7 Nicotinic Receptor Selective Ligands Public/Granted day:2009-08-27
Information query
