Invention Grant
US08093270B2 Solid pharmaceutical composition comprising (R)-(−)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman
有权
包含（R） - （ - ） - 2- [5-（4-氟苯基）-3-吡啶基甲基氨基甲基]苯并二氢吡喃的固体药物组合物
![Solid pharmaceutical composition comprising (R)-(−)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman](/docs/US/2012-01-10/US08093270B2/abs.jpg.600x600.jpg)
- Patent Title: Solid pharmaceutical composition comprising (R)-(−)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman
- Patent Title (中): 包含（R） - （ - ） - 2- [5-（4-氟苯基）-3-吡啶基甲基氨基甲基]苯并二氢吡喃的固体药物组合物
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Application No.: US11993324Application Date: 2006-06-09
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Publication No.: US08093270B2Publication Date: 2012-01-10
- Inventor: Klaus Kunath , Kirstin Heil , Roland Rupp
- Applicant: Klaus Kunath , Kirstin Heil , Roland Rupp
- Applicant Address: DE Darmstadt
- Assignee: Merck Patent GmbH
- Current Assignee: Merck Patent GmbH
- Current Assignee Address: DE Darmstadt
- Agency: Millen, White, Zelano & Branigan, P.C.
- Priority: EP05013293 20050621
- International Application: PCT/EP2006/005563 WO 20060609
- International Announcement: WO2006/136302 WO 20061228
- Main IPC: A01N43/40
- IPC: A01N43/40 ; A01N43/16 ; A01N43/06 ; A61K31/44 ; A61K31/35 ; A61K31/38
![Solid pharmaceutical composition comprising (R)-(−)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman](/abs-image/US/2012/01/10/US08093270B2/abs.jpg.150x150.jpg)
Abstract:
The invention relates to a solid pharmaceutical preparation containing (R)-(−)-2-[5-(4-fluorophenyl-3-pyridylmethylaminomethyl]chroman as an active substance and at least one sugar alcohol (e.g. mannitol, sorbitol) as a filler. Also disclosed is the production of said solid pharmaceutical preparation, which is provided with an increased shelf life also at elevated temperatures and can be used for the treatment of dyskinesia associated with Parkinson's disease.
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