Invention Grant
US08093369B2 Compositions for silencing the expression of VDAC1 and uses thereof
有权
用于沉默VDAC1表达的组合物及其用途
- Patent Title: Compositions for silencing the expression of VDAC1 and uses thereof
- Patent Title (中): 用于沉默VDAC1表达的组合物及其用途
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Application No.: US12088896Application Date: 2006-10-15
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Publication No.: US08093369B2Publication Date: 2012-01-10
- Inventor: Varda Shoshan-Barmatz , Salah Abu-Hamad
- Applicant: Varda Shoshan-Barmatz , Salah Abu-Hamad
- Applicant Address: IL Beer Sheva
- Assignee: Ben Gurion University of the Negev Research and Development Authority Ltd.
- Current Assignee: Ben Gurion University of the Negev Research and Development Authority Ltd.
- Current Assignee Address: IL Beer Sheva
- Agency: Fennemore Craig, P.C.
- Agent Rodney J. Fuller
- International Application: PCT/IL2006/001176 WO 20061015
- International Announcement: WO2007/043049 WO 20070419
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N5/00 ; C12N5/02 ; C12N15/11 ; C12Q1/68
Abstract:
The present invention relates generally to the down regulation of mitochondrial protein, voltage-dependent anion channel (VDAC1), expression by RNAi or antisense therapy. In particular, the present invention is directed to VDAC1 silencing molecules useful in regulating cell proliferation and to pharmaceutical compositions comprising same useful in the treatment of diseases associated with aberrant cell proliferation.
Public/Granted literature
- US20080267931A1 Compositions for Silencing the Expression of Vdac1 and Uses Thereof Public/Granted day:2008-10-30
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