A pointing device that can interface with a graphical user interface of a computer or other electronic device. The pointing device includes a body having an upper portion and an underside. Also included is a tracking assembly having at least one sensor to detect movement and output a control signal responsive to the detected movement. The pointing device further includes several customization features. The customization features include mechanical customization features and software customization features. At least some of the mechanical customization features are configured to be replaceable. Such replaceable customization features are releasably mechanically coupled to the pointing device body.