A cable user interface, such as a cable for audio headphones, enables control of one or more aspects of operation of a device to which such cable is connected. A user touches/applies pressure to the cable user interface, either along the full length of the cable, or to a localized part of the cable, in order to control the device. A mechanism is included for interfacing the pressure sensitive controller(s) to the device so that pressure/touch applied by a user can be translated to control of the device. In one embodiment, a headphone cable itself is an input device for volume and playback control of a portable media player.