A fluid filtration system is disclosed comprising a manifold assembly comprising a mounting bracket, an alignment collar connected to the mounting bracket, and a latch assembly moveable with respect to the mounting bracket and alignment collar. The system further comprises a filter cartridge comprising a filter cartridge outer surface and a cartridge latching structure formed on the filter cartridge outer surface to interact with the latch assembly. When the filter cartridge is aligned with the alignment collar and inserted into the manifold assembly, the filter cartridge is (i) latched into the manifold assembly by translating the filter cartridge into the manifold assembly to cause movement of the latch assembly to engage the cartridge latching structure; and (ii) unlatched from the manifold assembly by translating the filter cartridge into the manifold assembly to cause movement of the rotating latch assembly to disengage the cartridge latching structure.