Invention Grant
- Patent Title: Functional heavy chain antibodies, fragments thereof, library thereof and methods of production thereof
- Patent Title (中): 功能性重链抗体，其片段，文库及其生产方法
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Application No.: US11474521Application Date: 2006-06-23
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Publication No.: US08097251B2Publication Date: 2012-01-17
- Inventor: Serge Muyldermans , Karen Silence
- Applicant: Serge Muyldermans , Karen Silence
- Applicant Address: BE Zwijnaarde
- Assignee: Vlaams Interuniversitair Instituut Voor Biotechnologie VZW
- Current Assignee: Vlaams Interuniversitair Instituut Voor Biotechnologie VZW
- Current Assignee Address: BE Zwijnaarde
- Agency: Wolf, Greenfield & Sacks, P.C.
- Priority: EP01204037 20011024; JP2002/004184 20020111
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/30
Abstract:
The present invention relates to functional heavy chain antibodies, functional single domain heavy chain antibodies, functional VH domains, or functional fragments thereof including an amino acid which is neither a charged amino acid nor a C at position 45, and including an amino acid at position 103 independently chosen from the group consisting of R, G, K, S, Q, L, and P, and optionally an amino acid at position 108 independently chosen from the group consisting of Q, L and R, the positions determined according to the Kabat numbering.
Public/Granted literature
- US20070031424A1 Functional heavy chain antibodies, fragments thereof, library thereof and methods of production thereof Public/Granted day:2007-02-08
Information query
