Invention Grant
US08097443B2 Nucleotidyltransferases with enhanced nucleotide triphosphate flexibility
有权
具有增强的三磷酸核苷酸灵活性的核苷酸转移酶
- Patent Title: Nucleotidyltransferases with enhanced nucleotide triphosphate flexibility
- Patent Title (中): 具有增强的三磷酸核苷酸灵活性的核苷酸转移酶
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Application No.: US12103798Application Date: 2008-04-16
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Publication No.: US08097443B2Publication Date: 2012-01-17
- Inventor: Jon S. Thorson
- Applicant: Jon S. Thorson
- Applicant Address: US WI Madison
- Assignee: Wisconsin Alumni Research Foundation
- Current Assignee: Wisconsin Alumni Research Foundation
- Current Assignee Address: US WI Madison
- Agency: Quarles & Brady LLP
- Main IPC: C12N9/10
- IPC: C12N9/10 ; C12N15/00 ; C12P21/04 ; C12P9/00
Abstract:
The present invention provides mutant RmlA enzymes possessing an increased purine/pyrimidine bias in nucleotide triphosphate substrate specificity as compared to a corresponding non-mutated RmlA enzyme. Such enzymes expand the types of substrates that can be used in enzymatic glycorandomization methods thereby increasing diversity of chemical libraries.
Public/Granted literature
- US20080254509A1 NUCLEOTIDYL TRANSFERASES WITH ENHANCED NUCLEOTIDE TRIPHOSPHATE FLEXIBILITY Public/Granted day:2008-10-16
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