Invention Grant
US08097587B2 IGF-I protein variants for treating IGFBP-1-related disorders
有权
用于治疗IGFBP-1相关疾病的IGF-1蛋白质变体
- Patent Title: IGF-I protein variants for treating IGFBP-1-related disorders
- Patent Title (中): 用于治疗IGFBP-1相关疾病的IGF-1蛋白质变体
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Application No.: US11512046Application Date: 2006-08-28
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Publication No.: US08097587B2Publication Date: 2012-01-17
- Inventor: Yves Dubaquie , Paul J. Fielder , Henry B. Lowman , Deborah L. Mortensen
- Applicant: Yves Dubaquie , Paul J. Fielder , Henry B. Lowman , Deborah L. Mortensen
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Arnold & Porter LLP
- Agent Craig Svoboda; James A. Fox
- Main IPC: A61K38/30
- IPC: A61K38/30 ; C07K14/65
Abstract:
IGF-I variants having an alanine, glycine, or serine amino acid residue at position 16, 25, 49 or at positions 3 and 49 of native-sequence IGF-I are provided that are useful to treat a disorder characterized by dysregulation of the GH/IGF axis in a mammal, such as a renal disorder.
Public/Granted literature
- US20110003746A1 Protein variants Public/Granted day:2011-01-06
Information query
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