Invention Grant
US08097637B2 Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors
失效
苯甲酰哌啶衍生物作为5-HT2A和D3受体的双重调节剂
- Patent Title: Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors
- Patent Title (中): 苯甲酰哌啶衍生物作为5-HT2A和D3受体的双重调节剂
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Application No.: US12184272Application Date: 2008-08-01
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Publication No.: US08097637B2Publication Date: 2012-01-17
- Inventor: Luca Gobbi , Georg Jaeschke , Rosa Maria Rodriguez Sarmiento , Lucinda Steward
- Applicant: Luca Gobbi , Georg Jaeschke , Rosa Maria Rodriguez Sarmiento , Lucinda Steward
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- Priority: EP07114119 20070809
- Main IPC: A61K31/445
- IPC: A61K31/445 ; C07D211/32
Abstract:
The present invention relates to compounds of formula (I) wherein R1 and A are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use as medicaments. Compounds of general formula (I) have high affinity for the dopamine D3 and serotonin (5-Hydroxytryptamine; 5-HT) 5-HT2A receptors and are effective in the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.
Public/Granted literature
- US20090042943A1 BENZOYL-PIPERIDINE DERIVATIVES AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS Public/Granted day:2009-02-12
Information query
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