Invention Grant
- Patent Title: CD19 antibodies and their uses
- Patent Title (中): CD19抗体及其用途
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Application No.: US11917750Application Date: 2006-06-20
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Publication No.: US08097703B2Publication Date: 2012-01-17
- Inventor: Chetana Rao-Naik , David John King , Jie Liu , Haichun Huang , David B. Passmore , Alasdair Fraser Bell , Josephine M. Cardarelli , Chin Pan , To Uyen Thi Do , Sharline Chen , Dawn M. Tanamachi
- Applicant: Chetana Rao-Naik , David John King , Jie Liu , Haichun Huang , David B. Passmore , Alasdair Fraser Bell , Josephine M. Cardarelli , Chin Pan , To Uyen Thi Do , Sharline Chen , Dawn M. Tanamachi
- Applicant Address: US NJ Princeton
- Assignee: Medarex, Inc.
- Current Assignee: Medarex, Inc.
- Current Assignee Address: US NJ Princeton
- Agent Ashton J. Delauney
- International Application: PCT/US2006/024183 WO 20060620
- International Announcement: WO2007/002223 WO 20070104
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K17/00 ; C12P21/08 ; C07K14/00

Abstract:
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD19 with high affinity. Nucleic acid molecules encoding such CD19 antibodies, expression vectors, host cells and methods for expressing the CD19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD19 antibodies are also provided. Methods for detecting CD19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.
Public/Granted literature
- US20090142349A1 CD19 Antibodies And Their uses Public/Granted day:2009-06-04
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