Invention Grant
US08097719B2 Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
失效
新型结晶形式的美罗培南中间体和美罗培南的制备方法
- Patent Title: Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
- Patent Title (中): 新型结晶形式的美罗培南中间体和美罗培南的制备方法
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Application No.: US12255668Application Date: 2008-10-22
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Publication No.: US08097719B2Publication Date: 2012-01-17
- Inventor: Ashwin A. Khemka , Pravin B. Shejul , Amol V. Vyavahare , Dhirendra Kumar Pandey , Sachin N. Shete , Hanumant K. Jadhav , Nitn H. Kadam
- Applicant: Ashwin A. Khemka , Pravin B. Shejul , Amol V. Vyavahare , Dhirendra Kumar Pandey , Sachin N. Shete , Hanumant K. Jadhav , Nitn H. Kadam
- Applicant Address: IN Navi Mumbai
- Assignee: Genesen Labs
- Current Assignee: Genesen Labs
- Current Assignee Address: IN Navi Mumbai
- Priority: IN1483/MUM/2008 20080715
- Main IPC: C07D477/20
- IPC: C07D477/20
Abstract:
The present invention relates to novel crystalline form of (4-Nitrobenzyl (4R,5S,6S)-(3-{(3S,5S)-5-[(dimethylamino)carbonyl]-1-[(4-nitrophenoxy)carbonxyl]pyrrolidin-3-yl}thio-6-[(1R)-1-hydorxyehtyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0].hept-2-ene-2-carboxylate) of compound Formula I as well as an improved process for the preparation of meropenem trihydrate of compound Formula II wherein, PNB represent P-nitro benzyl group and PNZ represent P-nitrobenzyloxycarbonyl group.
Public/Granted literature
- US20090299057A1 MEROPENEM INTERMEDIATE IN NOVEL CRYSTALLINE FORM AND A METHOD OF MANUFACTURE OF MEROPENEM Public/Granted day:2009-12-03
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