Invention Grant
US08097754B2 Synthesis of (S)-(+)-3-(aminomethyl)-5-methyl hexanoic acid
失效
（S） - （+） - 3-（氨基甲基）-5-甲基己酸的合成
- Patent Title: Synthesis of (S)-(+)-3-(aminomethyl)-5-methyl hexanoic acid
- Patent Title (中): （S） - （+） - 3-（氨基甲基）-5-甲基己酸的合成
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Application No.: US12079225Application Date: 2008-03-24
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Publication No.: US08097754B2Publication Date: 2012-01-17
- Inventor: Vinod Kumar Kansal , Brijnath P. Chaurasia , Anand Prakash Tiwari , Shivaji Haribhau Shelke
- Applicant: Vinod Kumar Kansal , Brijnath P. Chaurasia , Anand Prakash Tiwari , Shivaji Haribhau Shelke
- Applicant Address: IL Petah Tiqva
- Assignee: Teva Pharmaceutical Industries Ltd.
- Current Assignee: Teva Pharmaceutical Industries Ltd.
- Current Assignee Address: IL Petah Tiqva
- Agency: Kenyon & Kenyon LLP
- Main IPC: C07C247/12
- IPC: C07C247/12
Abstract:
Provided are syntheses of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin via a chiral intermediate of the following formula 4 wherein Ar is a C6-10 aromatic group, R is a straight or branched C1-4 alkyl, ester, or carboxylic acid, and R1 is a straight or branched C1-5 alkyl, aralkyl, or substituted aralkyl.
Public/Granted literature
- US20080306292A1 Synthesis of (S)-(+)-3-(aminomethyl)-5-methyl hexanoic acid Public/Granted day:2008-12-11
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