Methods and hybrid matrix amplifiers are provided. In a method of calibrating a hybrid matrix amplifier of a wireless transceiver, a plurality of signal paths having a digital and an analog portion are toggled such that the analog portion of each of the plurality of signal paths is active only during a corresponding buffer capture interval of a calibration process. The signal paths carry signals to be transmitted by an antenna arrangement. Channel estimates for each of the plurality of signal paths are generated based only on sampling data collected during the corresponding buffer capture interval. The hybrid matrix amplifier is calibrated based on the generated channel estimates.