Method and apparatus for configuring a transmitter circuit to support multiple modes and/or frequency bands. In an embodiment, a pre-driver amplifier (pDA) in a transmit (TX) signal path is selectively bypassed by a controllable switch. The switch can be controlled based on a mode of operation of the transmitter circuit. Further techniques are disclosed for selectively coupling the output of a driver amplifier (DA) to at least one of a plurality of off-chip connections, each connection coupling the DA output to a set of off-chip components.