A data processing technique is provided. In one embodiment, a computer-implemented method includes accessing individual patient deviation maps indicative of a structural difference and a functional difference, respectively, of at least one anatomical region of a patient with respect to standardized reference image data. The method may also include generating a composite patient deviation map indicative of both the structural difference and the functional difference based on at least the individual patient deviation maps, and outputting the composite patient deviation map. Additional methods, systems, and manufactures are also disclosed.