A method for preparing and replying to multi-party e-mails is provided. The method includes opening an e-mail composition window in an e-mail application for generating an e-mail, specifying one or more recipients from a plurality of recipient groups for the e-mail, creating one or more response sections, identifying at least one recipient for each of the response sections, and sending the e-mail. The creating step further includes creating a general section in the e-mail. The method further includes selecting a delivery option from a plurality of delivery options for the e-mail prior to sending the e-mail and receiving one or more return receipts based on the delivery option selected in the e-mail sent. The method further includes selecting a response section in a received e-mail, and generating a reply to the response section in a reply e-mail composition window containing the response section.