Methods and apparatus for applying a patch to an interior surface of a tire, the apparatus comprising a patch holder having the top surface shaped to a contour of the interior surface of the tire, the patch holder comprising a patch receptacle and a plurality of orifices extending there through in fluid communication with a vacuum source, and, an adhesive barrier surrounding the patch receptacle. The steps of a method include placing a patch into a patch receptacle in a tire patch holder, the patch holder having the top surface shaped to a contour of the interior tire surface, directing the patch holder to obliquely contact the interior surface of the tire, and, pressing the patch into substantial adhesive contact with the interior tire surface.