A vending machine includes a storage/display region, a dispensing chamber including a product access opening, and an anti-pilfer device that prevents unauthorized removal of products from the storage/display region through the product access opening. A delivery door is provided which can be shifted from a closed position to an open position to enable the removal of products from the dispensing chamber. The anti-pilfer device includes a plate coupled to a lower portion of the delivery door. When the delivery door is moved from the closed position, the anti-pilfer plate shifts, over a guide element, into a position that prevents products from being withdrawn from the storage/display area. Preferably, the storage/display region and dispensing chamber are separated by a product door, with the anti-pilfer plate preventing the product door from opening when the delivery door is shifted from the closed position.