An elongate probe, with a suction channel extending longitudinally along the probe, is inserted into a patient so that a distal tip of the probe is in contact with a fibroid mass inside the patient. Thereafter the probe is ultrasonically vibrated so that the distal tip has an excursion amplitude or distance greater than 275 microns. During probe vibration, suction is applied to the channel at a vacuum level greater than 24″ Hg to thereby maintain the target tissue mass in engagement with the distal tip during the vibrating of the probe and enable ablation of at least a selectable portion of the target tissue mass.