Invention Grant
- Patent Title: Purification and characterization of cytotoxic lymphocyte maturation factor and monoclonal antibodies thereto
- Patent Title (中): 细胞毒性淋巴细胞成熟因子及其单克隆抗体的纯化和表征
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Application No.: US10267565Application Date: 2002-10-08
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Publication No.: US08110187B2Publication Date: 2012-02-07
- Inventor: Maurice Kent Gately , Ulrich Andreas Gubler , Jeffrey David Hulmes , Frank John Podlaski , Alvin Seth Stern , Richard Anthony Chizzonite , Yu-Ching Eugene Pan
- Applicant: Maurice Kent Gately , Ulrich Andreas Gubler , Jeffrey David Hulmes , Frank John Podlaski , Alvin Seth Stern , Richard Anthony Chizzonite , Yu-Ching Eugene Pan
- Applicant Address: US NJ Nutley
- Assignee: Hoffman-La Roche Inc.
- Current Assignee: Hoffman-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agency: Yankwich & Associates, P.C.
- Agent Leon R. Yankwich; Thomas R. Berka
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/24

Abstract:
The present invention is a novel cytokine protein called IL-12 or Cytotoxic Lymphocyte Maturation Factor (CLMF) which is produced and synthesized by human NC-37 B lymphoblastoid cells (American Type Culture Collection, Rockville, Md.). CLMF synergistically induces with low concentrations of IL-2 the cytolytic activity of Lymphokine Activated Killer (LAK) cells, and CLMF is capable of stimulating T-cell growth.Also claimed are the cloned gene for CLMF, its recombination in a suitable vector, the transformed cells containing said vector, the recombinant protein produced by the transformed cells and antibodies to CLMF.
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