Invention Grant
US08110192B2 Human immunodeficiency virus type 1 (HIV-1)-neutralizing human single-chain antibodies with improved breadth and potency
失效
人类免疫缺陷病毒1型（HIV-1） - 中和人单链抗体具有改善的广度和效力
- Patent Title: Human immunodeficiency virus type 1 (HIV-1)-neutralizing human single-chain antibodies with improved breadth and potency
- Patent Title (中): 人类免疫缺陷病毒1型（HIV-1） - 中和人单链抗体具有改善的广度和效力
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Application No.: US12508913Application Date: 2009-07-24
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Publication No.: US08110192B2Publication Date: 2012-02-07
- Inventor: Dimiter S. Dimitrov , Mei-Yun Zhang
- Applicant: Dimiter S. Dimitrov , Mei-Yun Zhang
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Leydig, Voit & Mayer, Ltd.
- Main IPC: A61K39/42
- IPC: A61K39/42 ; A61K39/21 ; C07K16/00 ; C12P21/08
Abstract:
The present invention provides an antibody to human immunodeficiency virus (HIV) envelope glycoprotein that can recognize one or more strains of HIV, wherein the epitope of HIV recognized by the antibody is inducible, and wherein the antibody binding to the epitope is enhanced by the presence of CD4 and the HIV co-receptor, and related fusion proteins, conjugates, nucleic acids, vectors, host cells, compositions and methods of use to inhibit an infection of a human at risk of becoming infected with HIV, to reduce the severity of an infection of a human infected with HIV, and to treat an infection of a human with HIV.
Public/Granted literature
- US20090291493A1 HUMAN IMMUNODEFICIENCY VIRUS-NEUTRALIZING ANTIBODIES WITH IMPROVED BREADTH AND POTENCY Public/Granted day:2009-11-26
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