Invention Grant
US08110218B2 Compositions and methods for less immunogenic protein-lipid complexes
有权
较少免疫原性蛋白质 - 脂质复合物的组合物和方法
- Patent Title: Compositions and methods for less immunogenic protein-lipid complexes
- Patent Title (中): 较少免疫原性蛋白质 - 脂质复合物的组合物和方法
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Application No.: US12181178Application Date: 2008-07-28
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Publication No.: US08110218B2Publication Date: 2012-02-07
- Inventor: Sathy V. Balu-Iyer , Robert Straubinger , Karthik Ramani , Razvan D. Miclea
- Applicant: Sathy V. Balu-Iyer , Robert Straubinger , Karthik Ramani , Razvan D. Miclea
- Applicant Address: US NY Amherst
- Assignee: The Research Foundation of State University of New York
- Current Assignee: The Research Foundation of State University of New York
- Current Assignee Address: US NY Amherst
- Agency: Hodgson Russ LLP
- Main IPC: A61K9/127
- IPC: A61K9/127 ; A61K38/37
Abstract:
The present invention provides compositions and methods for reducing the immunogenicity and increasing the circulating half-life of therapeutic proteins such as Factor VIII. The compositions comprise lipidic structures such as liposomes, micelles and cochleates comprising a negatively charged lipid and polyethylene glycol derivatized phosphatidyl ethanolamine.
Public/Granted literature
- US20090053297A1 COMPOSITIONS AND METHODS FOR LESS IMMUNOGENIC PROTEIN-LIPID COMPLEXES Public/Granted day:2009-02-26
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