Invention Grant
- Patent Title: Culture of mammalian pluripotent stem cells in the presence of hyaluronan induces differentiation into multi-lineage progenitor cells
- Patent Title (中): 在透明质酸存在下哺乳动物多能干细胞的培养诱导分化成多谱系祖细胞
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Application No.: US11817652Application Date: 2006-03-03
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Publication No.: US08110400B2Publication Date: 2012-02-07
- Inventor: Paul A. De Sousa
- Applicant: Paul A. De Sousa
- Applicant Address: GB Roslin
- Assignee: Roslin Foundation
- Current Assignee: Roslin Foundation
- Current Assignee Address: GB Roslin
- Agency: Law Office of Salvatore Arrigo and Scott Lee, LLP
- Priority: GB0504427.6 20050303
- International Application: PCT/GB2006/000800 WO 20060303
- International Announcement: WO2006/092633 WO 20060908
- Main IPC: C12N15/02
- IPC: C12N15/02
Abstract:
A method for the differentiation of mammalian pluripotent stem (PS) cells into a mortal multi-lineage progenitor cell population is provided which comprises culturing the pluripotent stem cells in the presence of Hyaluronan (HA). The mortal multi-lineage progenitor cell population may be a population of mesenchymal stem cells. The mortal multi-lineage progenitor cell population may form cells of the mesodermal lineage, suitably osteoblasts. Alternatively, the mortal multi-lineage progenitor cell population may form cells of the endodermal lineage or of the ectodermal lineage, which may be neuronal progenitors.
Public/Granted literature
- US20090123430A1 METHOD FOR DIFFERENTIATION OF STEM CELLS Public/Granted day:2009-05-14
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