Invention Grant
US08110573B2 Pyrazole compounds that modulate the activity of CDK, GSK and aurora kinases
失效
调节CDK，GSK和极光激酶活性的吡唑化合物
- Patent Title: Pyrazole compounds that modulate the activity of CDK, GSK and aurora kinases
- Patent Title (中): 调节CDK，GSK和极光激酶活性的吡唑化合物
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Application No.: US11813031Application Date: 2005-12-30
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Publication No.: US08110573B2Publication Date: 2012-02-07
- Inventor: Valerio Berdini , Maria Grazia Carr , Adrian Liam Gill , Steven Howard , Eva Figueroa Navarro , Gary Trewartha , David Charles Rees , Mladen Vinkovic , Paul Graham Wyatt
- Applicant: Valerio Berdini , Maria Grazia Carr , Adrian Liam Gill , Steven Howard , Eva Figueroa Navarro , Gary Trewartha , David Charles Rees , Mladen Vinkovic , Paul Graham Wyatt
- Applicant Address: GB Cambridge
- Assignee: Astex Therapeutics Limited
- Current Assignee: Astex Therapeutics Limited
- Current Assignee Address: GB Cambridge
- Agency: Heslin Rothenberg Farley & Mesiti P.C.
- Priority: GB0428552.4 20041230; GB0428554.0 20041230
- International Application: PCT/GB2005/005097 WO 20051230
- International Announcement: WO2006/070195 WO 20060706
- Main IPC: A61K31/535
- IPC: A61K31/535 ; C07D413/14
Abstract:
The invention provides a compound of the formula (I): or a salt, solvate, tautomer or N-oxide thereof, wherein M is selected from a group D1 and a group D2: and R′, E, A and X are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds, processes for making the compounds and the use of the compounds in the prophylaxis or treatment of a disease state mediated by a CDK kinase, GSK-3 kinase or Aurora kinase.
Public/Granted literature
- US20080132495A1 Pyrazole Compounds that Modulate the Activity of Cdk, Gsk and Aurora Kinases Public/Granted day:2008-06-05
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