Invention Grant
US08110588B2 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors
失效
1,2,3-三唑衍生物可用作烟碱乙酰胆碱受体的调节剂
- Patent Title: 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors
- Patent Title (中): 1,2,3-三唑衍生物可用作烟碱乙酰胆碱受体的调节剂
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Application No.: US12672252Application Date: 2008-08-06
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Publication No.: US08110588B2Publication Date: 2012-02-07
- Inventor: Antonio Nardi , Jeppe Kejser Christensen , Dan Peters , Gunnar M. Olsen , Tino Dyhring
- Applicant: Antonio Nardi , Jeppe Kejser Christensen , Dan Peters , Gunnar M. Olsen , Tino Dyhring
- Applicant Address: DK Ballerup
- Assignee: Neurosearch A/S
- Current Assignee: Neurosearch A/S
- Current Assignee Address: DK Ballerup
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: DK200701134 20070808
- International Application: PCT/EP2008/060307 WO 20080806
- International Announcement: WO2009/019278 WO 20090212
- Main IPC: C07D413/10
- IPC: C07D413/10 ; C07D249/06 ; A61K31/4192 ; A61K31/4245
Abstract:
This invention relates to novel 1,2,3-triazole derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
Public/Granted literature
- US20100222398A1 NOVEL 1,2,3-TRIAZOLE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS Public/Granted day:2010-09-02
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