Invention Grant
- Patent Title: 2-aminoaryloxazole compounds as tyrosine kinase inhibitors
- Patent Title (中): 2-氨基吡唑化合物作为酪氨酸激酶抑制剂
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Application No.: US12654957Application Date: 2010-01-11
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Publication No.: US08110591B2Publication Date: 2012-02-07
- Inventor: Alain Moussy , Camille Wermuth , David Grierson , Abdellah Benjahad , Martine Croisy , Marco Ciufolini , Bruno Giethlen
- Applicant: Alain Moussy , Camille Wermuth , David Grierson , Abdellah Benjahad , Martine Croisy , Marco Ciufolini , Bruno Giethlen
- Applicant Address: FR Paris FR Paris FR Paris
- Assignee: AB Science,Centre National de la Recherche Scientifique (CNRS),Institut Curie
- Current Assignee: AB Science,Centre National de la Recherche Scientifique (CNRS),Institut Curie
- Current Assignee Address: FR Paris FR Paris FR Paris
- Agency: Foley & Lardner LLP
- Main IPC: A61K31/421
- IPC: A61K31/421 ; C07D263/30
Abstract:
The present invention relates to novel compounds selected from 2-aminoaryloxazoles that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic and degenerative disorders. More particularly, these compounds are potent and selective c-kit, bcr-abl, FGFR3 and/or Flt-3 inhibitors.
Public/Granted literature
- US20100113471A1 2-Aminoaryloxazole compounds as tyrosine kinase inhibitors Public/Granted day:2010-05-06
Information query
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