Invention Grant
US08110657B2 Polypeptides and polynucleotides for enhancing immune reactivity to HER-2 protein
失效
用于增强对HER-2蛋白的免疫反应性的多肽和多核苷酸
- Patent Title: Polypeptides and polynucleotides for enhancing immune reactivity to HER-2 protein
- Patent Title (中): 用于增强对HER-2蛋白的免疫反应性的多肽和多核苷酸
-
Application No.: US12683114Application Date: 2010-01-06
-
Publication No.: US08110657B2Publication Date: 2012-02-07
- Inventor: Pravin Kaumaya
- Applicant: Pravin Kaumaya
- Applicant Address: US OH Columbus
- Assignee: The Ohio State University
- Current Assignee: The Ohio State University
- Current Assignee Address: US OH Columbus
- Agency: Calfee, Halter & Griswold LLP
- Main IPC: A61K38/00
- IPC: A61K38/00
Abstract:
Compositions for stimulating the immune system and for treating malignancies associated with overexpression of the HER-2 protein are provided. Such compositions include immunogenic epitopes of the HER-2 proteins and chimeric and multivalent peptides which comprise such epitopes. The present invention also relates to polynucleotides which encode the chimeric peptides. Also provided are pharmaceutical compositions comprising such immunogenic compositions. Methods for stimulating an immune response to HER-2 protein are provided. Methods for treating breast cancer, ovarian cancer, prostate cancer, colon cancer and lung cancer are provided.
Public/Granted literature
- US20100112071A1 POLYPEPTIDES AND POLYNUCLEOTIDES FOR ENHANCING IMMUNE REACTIVITY TO HER-2 PROTEIN Public/Granted day:2010-05-06
Information query
IPC分类:
