Invention Grant
US08110681B2 Compounds for the treatment of spinal muscular atrophy and other uses
失效
用于治疗脊髓性肌肉萎缩和其他用途的化合物
- Patent Title: Compounds for the treatment of spinal muscular atrophy and other uses
- Patent Title (中): 用于治疗脊髓性肌肉萎缩和其他用途的化合物
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Application No.: US12293268Application Date: 2007-03-13
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Publication No.: US08110681B2Publication Date: 2012-02-07
- Inventor: Jill Heemskerk , Keith D. Barnes , John M. McCall , Graham Johnson , David Fairfax , Matthew Robert Johnson
- Applicant: Jill Heemskerk , Keith D. Barnes , John M. McCall , Graham Johnson , David Fairfax , Matthew Robert Johnson
- Applicant Address: US DC Washington US NY Albany US CA San Diego
- Assignee: The United States of America as represented by the Secretary, Department of Health and Human Services,Albany Molecular Research, Inc.,Science Applications International Inc. (SAIC)
- Current Assignee: The United States of America as represented by the Secretary, Department of Health and Human Services,Albany Molecular Research, Inc.,Science Applications International Inc. (SAIC)
- Current Assignee Address: US DC Washington US NY Albany US CA San Diego
- Agency: Leydig, Voit & Mayer, Ltd.
- International Application: PCT/US2007/006772 WO 20070313
- International Announcement: WO2007/109211 WO 20070927
- Main IPC: C07D413/04
- IPC: C07D413/04 ; C07D239/24 ; C07D401/04 ; C07D209/46 ; C07D206/56 ; A61K31/535 ; A61K31/44 ; A61K31/40 ; A01N43/54
Abstract:
Compounds of Formula (I) or (II) useful for the treatment of spinal muscular atrophy or other uses, as well as methods of using such compounds to increase SMN expression, increase EAAT2 expression, or increase the expression of a nucleic acid that encodes a translational stop codon introduced by mutation or frameshift.
Public/Granted literature
- US20090312323A1 COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES Public/Granted day:2009-12-17
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