Invention Grant
- Patent Title: Method for producing indole derivative having piperidine ring
- Patent Title (中): 具有哌啶环的吲哚衍生物的制造方法
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Application No.: US11914115Application Date: 2006-11-05
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Publication No.: US08110688B2Publication Date: 2012-02-07
- Inventor: Naoyuki Shimomura , Atsushi Kamada , Mamoru Miyazawa , Koichi Ito
- Applicant: Naoyuki Shimomura , Atsushi Kamada , Mamoru Miyazawa , Koichi Ito
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: WOPCT/JP2005/008632 20050511; JP2005-325713 20051110
- International Application: PCT/JP2006/309461 WO 20061105
- International Announcement: WO2006/121106 WO 20061116
- Main IPC: C07D405/14
- IPC: C07D405/14 ; C07D311/22
Abstract:
It is possible to commercially advantageously prepare 1-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-y)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide by coupling (7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)acetaldehyde, which is obtained by oxidizing 8-(2-hydroxyethyl)-7-methoxy-2,2-dimethylchroman-4-one, with N-methyl-1-(piperidin-4-yl)-1H-indole-6-carboxamide.
Public/Granted literature
- US20100197926A1 METHOD FOR PRODUCING INDOLE DERIVATIVE HAVING PIPERIDINE RING Public/Granted day:2010-08-05
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