Invention Grant
US08110691B2 Industrial process for the synthesis of 17α-acetoxy-11β-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione and new intermediates of the process
有权
合成17α-乙酰氧基-11β-[4-（N，N-二甲基 - 氨基） - 苯基] -19-去甲基-4,9-二烯-3,20-二酮的工业方法和该方法的新中间体
![Industrial process for the synthesis of 17α-acetoxy-11β-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione and new intermediates of the process](/docs/US/2012-02-07/US08110691B2/abs.jpg.600x600.jpg)
- Patent Title: Industrial process for the synthesis of 17α-acetoxy-11β-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione and new intermediates of the process
- Patent Title (中): 合成17α-乙酰氧基-11β-[4-（N，N-二甲基 - 氨基） - 苯基] -19-去甲基-4,9-二烯-3,20-二酮的工业方法和该方法的新中间体
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Application No.: US12303160Application Date: 2007-05-18
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Publication No.: US08110691B2Publication Date: 2012-02-07
- Inventor: Lajosné Dancsi , György Visky , Zoltán Tuba , János Csörgei , Csaba Molnár , Endréné Magyari
- Applicant: Lajosné Dancsi , György Visky , Zoltán Tuba , János Csörgei , Csaba Molnár , Endréné Magyari
- Applicant Address: HU Budapest
- Assignee: Richter Gedeon Nyrt.
- Current Assignee: Richter Gedeon Nyrt.
- Current Assignee Address: HU Budapest
- Agent Jason D. Voight
- Priority: HU0600491 20060614
- International Application: PCT/HU2007/000045 WO 20070518
- International Announcement: WO2007/144674 WO 20071221
- Main IPC: C07J7/00
- IPC: C07J7/00
![Industrial process for the synthesis of 17α-acetoxy-11β-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione and new intermediates of the process](/abs-image/US/2012/02/07/US08110691B2/abs.jpg.150x150.jpg)
Abstract:
A new industrial process for the synthesis of solvate-free 17α-acetoxy-11β-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB-2914] of formula (I) which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII) and (VIII) used as intermediates in the process.
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