Certain aspects of a multi-channel signal synchronizer may comprise receiving a plurality of clock signals from a plurality of clock signal sources, wherein a portion of the received plurality of clock signals may be out of synchronization with a remaining portion of the received plurality of clock signals. A plurality of data signals may be received from a plurality of data signal sources, wherein a portion of the received plurality of data signals may be out of synchronization with a remaining portion of the received plurality of data signals. The received portion of plurality of clock signals and data signals may be synchronized to the received remaining portion of plurality of clock signals and data signals utilizing bit alignment and sample alignment. A plurality of synchronized output signals may be generated based on the synchronized received plurality of clock signals and synchronized received plurality of data signals.