A display panel driver including a compression circuit configured to, when receiving image data of a set of pixels of a target block, generate compressed image data corresponding to the target block by compressing the image data, the number of the set of pixels being equal to or more than four, an image memory configured to store the compressed image data, a decompression circuit configured to generate decompressed image data by decompressing the compressed image data reading from the image memory, and a drive circuit configured to drive a display panel in response to the decompressed image data, wherein the compression circuit selects one of a plurality of compression methods based on a correlation between the image data of the set of pixels of the target block, and generates the compressed image data by using the selected compression method.