A system and method for activating a subscriber identification module (SIM) based mobile device in a PCS/ANSI type wireless network. The method comprises pre-programming the SIM card of the mobile device with temporary activation identifiers, such as an international mobile station identity (IMSI) and/or a mobile identification number (MIN), and a temporary electronic serial number. The temporary electronic serial number, rather than the mobile device actual electronic serial number, is used to identify the mobile device during registration and activation. The network identifies the temporary electronic serial number associated with the SIM vendor and invokes an over-the-air activation procedure especially for the SIM card mobile devices. A SIM-over-the-air-activation processor is notified to perform the activation for that mobile device on the PCS wireless network. Authentication of the mobile device may be bypassed and the mobile device is instructed to transmit its actual electronic serial number for future registrations. Once the activation process is completed, the temporary activation identifiers are overwritten.