A detection system which provides for continuous background estimation removal from a sequence of spectra. A panoramic field of regard may be partitioned into a large number of fields of view (FOVs). An FOV may have a chemical vapor cloud. The small FOV may maximize detection of the cloud. Such detection may require removing the spectral characteristics other than that of the target cloud. This may amount to removal of background spectra with an estimated background developed from one or more FOVs which may or may not be similar to the background of the FOV with the target cloud. A number of estimated background spectra of the other FOVs may be used individually to greatly increase the detection probability of the target chemical.