Durable protective covers for drains and other holes are provided which prevent spills and unwanted liquids from flowing therein. The protective covers include a durable backing layer and a pliable, tacky sealing layer which conforms and adheres to a surface surrounding the drain to reduce or eliminate the flow of liquids into the drain. A low-density bonding layer is provided between the pliable, tacky sealing layer and the durable backing layer in order to provide significantly improved adherence between the layers.