A cartridge for an appliance for personal care, such as skin, dental or hair treatment includes a main body, a dispensing structure for dispensing a substance, such as a liquid, a paste or a gel, and a cartridge detachably connected to the main body. The cartridge bounds a reservoir space for holding the substance to be dispensed and includes a flexible wall part bounding the reservoir space for allowing reservoir space volume to accommodate to a volume of the substance filled therein and volumes of the substance dispensed therefrom; a rigid wall part also bounding the reservoir space, and a rigid housing. The flexible wall part is connected to the rigid housing along a contour of the rigid wall part.