Invention Grant
- Patent Title: Humanized anti-tag-72 monoclonal antibodies
- Patent Title (中): 人源化抗标签72单克隆抗体
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Application No.: US11628423Application Date: 2005-05-06
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Publication No.: US08119132B2Publication Date: 2012-02-21
- Inventor: Hyo Jeong Hong , Sang Jick Kim , Sun Ok Yoon , Myeong Hee Jang , Keun Soo Kim , Tae Sup Lee , Chang Woon Choi
- Applicant: Hyo Jeong Hong , Sang Jick Kim , Sun Ok Yoon , Myeong Hee Jang , Keun Soo Kim , Tae Sup Lee , Chang Woon Choi
- Applicant Address: KR Daejeon
- Assignee: Korea Research Institute of Bioscience and Biotech
- Current Assignee: Korea Research Institute of Bioscience and Biotech
- Current Assignee Address: KR Daejeon
- Agency: Casimir Jones SC
- Priority: KR10-2004-0041199 20040605
- International Application: PCT/KR2005/001322 WO 20050506
- International Announcement: WO2005/121180 WO 20051222
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/18
Abstract:
The present invention relates to humanized antibodies specific to a tumor-associated glycoprotein, TAG-72, and anticancer compositions comprising the humanized antibodies. In detail, the present invention relates to a humanized antibody which has enhanced antigen binding affinity by mutating a heavy chain of a humanized antibody PXA/HzK specific for TAG-72, an antibody which is prepared by replacing a light chain of the humanized antibody with a human light chain, and anticancer compositions including the antibodies.
Public/Granted literature
- US20080279847A1 Humanized Anti-Tag-72 Monoclonal Antibodies Public/Granted day:2008-11-13
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