Invention Grant
US08119381B2 Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity
有权
合理设计的大范围核酸酶具有改变的序列特异性和DNA结合亲和力
- Patent Title: Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity
- Patent Title (中): 合理设计的大范围核酸酶具有改变的序列特异性和DNA结合亲和力
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Application No.: US13245596Application Date: 2011-09-26
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Publication No.: US08119381B2Publication Date: 2012-02-21
- Inventor: James Jefferson Smith , Derek Jantz , Homme W. Hellinga
- Applicant: James Jefferson Smith , Derek Jantz , Homme W. Hellinga
- Applicant Address: US NC Durham
- Assignee: Duke University
- Current Assignee: Duke University
- Current Assignee Address: US NC Durham
- Agency: Wilmer Cutler Pickering Hale and Dorr LLP
- Main IPC: C07K14/00
- IPC: C07K14/00 ; C12N9/16 ; C12P21/00 ; C12Q1/68
Abstract:
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
Public/Granted literature
- US20120015421A1 RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY Public/Granted day:2012-01-19
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