Invention Grant
- Patent Title: Rhodococcus erythropolis strain
- Patent Title (中): 红球菌红细菌菌株
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Application No.: US12506596Application Date: 2009-07-21
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Publication No.: US08119389B2Publication Date: 2012-02-21
- Inventor: Nigel Ian Bowers , Paul M. Skonezny , Gregory L. Stein , Thomas Franceschini , Shu-Jen Chiang , Wendy L. Anderson , Li You , Zizhuo Xing
- Applicant: Nigel Ian Bowers , Paul M. Skonezny , Gregory L. Stein , Thomas Franceschini , Shu-Jen Chiang , Wendy L. Anderson , Li You , Zizhuo Xing
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent John F. Levis
- Main IPC: C12N1/20
- IPC: C12N1/20
Abstract:
The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648.
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